First describe the similarities or differences between the cyclooxygenase-1 (COX-1) and COX-2 pathways and state which (pathologic) physiologic process is mainly responsible for analgesia, antiinflammatory activity, antipyresis, bleeding tendencies, and gastric mucosal damage and discuss the beneficial and adverse actions of nonsteroidal antiinflammatory drugs (NSAIDs) and the basic mechanisms by which they occur. Also, identify situations in which aspirin should not be used, even for relief of mild or episodic headache or fever. Also, state which of the alternative over-the-counter (OTC) analgesic/antipyretic drugs would be a more acceptable alternative to aspirin and why. Not only but also compare and contrast the signs and symptoms of acute poisoning with aspirin and with acetaminophen, the time course of the signs and symptoms and underlying causes, and the management of these conditions.
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